Vitamin D3 supplementation and treatment outcomes in patients with depression (D3-vit-dep)

BMC Research Notes

Manan Pareek¹  Anne Schmedes²  Jens Peter Hansen³  Connie Thurøe Nielsen³  Allan Hvolby³  Erik Dahl⁴  Tomas Toft⁵ 

[1] Cardiology Section, Department of Internal Medicine, Holbaek Hospital;Clinical Chemical Laboratory, Lillebaelt Hospital;Mental Health Services in Esbjerg, Region of Southern Denmark;Mental Health Services in Svendborg, Region of Southern Denmark;Mental health Services in Odense, Region of Southern Denmark;

关键词: Depression;    Vitamin D deficiency;    Randomised controlled trial;    Drug therapy;    Double-blind method;   

DOI  :  10.1186/s13104-019-4218-z

来源: DOAJ

【 摘 要 】

Abstract Objective To examine whether vitamin D supplementation in patients with depression would result in a reduction in Hamilton D-17 depression score (primary outcome) at 3 and 6 months compared to controls and to explore the correlations between serum vitamin D and symptoms of depression, wellbeing, systolic blood pressure, and waist circumference. In this outpatient multicentre study conducted between 2010 and 2013, patients, 18–65 years old, diagnosed with mild to severe depression were randomly assigned to receive D supplementation 70 micrograms daily or placebo on top of standard treatment. Participants, care givers and those assessing the outcomes were blinded to group assignment. Results At baseline, 23 patients had a normal 25(OH)D level, 22 had insufficiency (< 25 nmol/L), and 17 had deficiency (25–50 nmol/L). No significant reduction in depression was seen after vitamin D supplementation compared to placebo at Hamilton (18.4–18.0; p = 0.73 at 12 weeks). Vitamin D supplementation did not provide a reduction in symptom score among patients with depression. Trial registration The trial was registered in the National Board of Health (EudraCT: 2011-002585-20) and in ClinicalTrials.Gov (NCT01390662).

【 授权许可】

Unknown