Range, routing and kinetics of rod signaling in primate retina

eLife

Fred Rieke¹  Anthony W Azevedo¹  William N Grimes¹  Jacob Baudin¹ 

[1] Department of Physiology and Biophysics, University of Washington, Seattle, United States;

关键词: rod vision;    sensory processing;    parallel processing;    neural computation;   

DOI  :  10.7554/eLife.38281

来源: DOAJ

【 摘 要 】

Stimulus- or context-dependent routing of neural signals through parallel pathways can permit flexible processing of diverse inputs. For example, work in mouse shows that rod photoreceptor signals are routed through several retinal pathways, each specialized for different light levels. This light-level-dependent routing of rod signals has been invoked to explain several human perceptual results, but it has not been tested in primate retina. Here, we show, surprisingly, that rod signals traverse the primate retina almost exclusively through a single pathway – the dedicated rod bipolar pathway. Identical experiments in mouse and primate reveal substantial differences in how rod signals traverse the retina. These results require reevaluating human perceptual results in terms of flexible computation within this single pathway. This includes a prominent speeding of rod signals with light level – which we show is inherited directly from the rod photoreceptors themselves rather than from different pathways with distinct kinetics.

【 授权许可】

Unknown