Facile synthesis of calcium carbonate/polyacrylic acid hydrogels for pH-responsive delivery of cytarabine

Journal of Saudi Chemical Society

Chengqiang Ding¹  Zhiguo Xu¹  Zheng-Zhi Yin¹  Yong Kong²  Lefeng Liu³  Yanshan Sheng³  Yang Liu³ 

[1] Gene Engineering Co., Ltd., Huzhou 313000, China;College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China;;Xiehe Union East China Stem Cell &

关键词: CaCO3 nanospheres;    Polyacrylic acid;    Hydrogels;    pH-Responsive delivery;    Cytarabine;   

DOI  :  

来源: DOAJ

【 摘 要 】

Cytarabine (Cyt) encapsulated calcium carbonate (CaCO3) nanospheres were facilely synthesized through a simple co-precipitation method, and the Cyt encapsulated CaCO3 nanospheres (CaCO3/Cyt) were modified by polyacrylic acid (PAA) hydrogels through in situ polymerization of acrylic acid (AA) monomer on the surface of the CaCO3/Cyt. Successful preparation of the Cyt loaded CaCO3/PAA hydrogels were confirmed by the characterization of SEM, TEM and FT-IR. Premature release of Cyt in acidic medium (pH = 1.2) could be effectively circumvented by the introduction of the PAA hydrogels. More importantly, pH-responsive delivery of Cyt from the as-prepared CaCO3/PAA hydrogels could be achieved due to the pH-sensitivity of the PAA. Although the highest swelling ratio of PAA was obtained at pH 7.3 (27.7), the highest cumulative release of Cyt from the carrier was achieved at pH 5.3 (86.75%), which might be attributed to the high stability of CaCO3 at pH 7.3. That is to say, the highest cumulative release of Cyt at pH 5.3 was a compromise by considering the relatively high swelling ratio of PAA and the relatively low stability of CaCO3.

【 授权许可】

Unknown