Thermal Activation of Thin Filaments in Striated Muscle

Frontiers in Physiology

Seine A. Shintani¹  Fuyu Kobirumaki-Shimozawa²  Norio Fukuda²  Shin’ichi Ishiwata³  Kotaro Oyama⁴  Shuya Ishii⁵ 

[1] Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai, Japan;Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan;Department of Physics, Faculty of Science and Engineering, Waseda University, Tokyo, Japan;PRESTO, Japan Science and Technology Agency, Saitama, Japan;Quantum Beam Science Research Directorate, National Institutes for Quantum and Radiological Science and Technology, Gunma, Japan;

关键词: actomyosin;    Ca2+ sensitivity;    cardiac muscle;    skeletal muscle;    temperature;    tropomyosin;   

DOI  :  10.3389/fphys.2020.00278

来源: DOAJ

【 摘 要 】

In skeletal and cardiac muscles, contraction is triggered by an increase in the intracellular Ca2+ concentration. During Ca2+ transients, Ca2+-binding to troponin C shifts the “on–off” equilibrium of the thin filament state toward the “on” sate, promoting actomyosin interaction. Likewise, recent studies have revealed that the thin filament state is under the influence of temperature; viz., an increase in temperature increases active force production. In this short review, we discuss the effects of temperature on the contractile performance of mammalian striated muscle at/around body temperature, focusing especially on the temperature-dependent shift of the “on–off” equilibrium of the thin filament state.

【 授权许可】

Unknown