The Promise of the Zebrafish Model for Parkinson’s Disease: Today’s Science and Tomorrow’s Treatment

Frontiers in Genetics

Wisam Nabeel Ibrahim¹  Mohd Hamzah Mohd Nasir²  Wael M. Y. Mohamed³  Khairiah Razali⁴  Noratikah Othman⁵  Abd Almonem Doolaanea⁷  Jaya Kumar⁸  Norlinah Mohamed Ibrahim⁹ 

[1] Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar;Central Research and Animal Facility (CREAM), Kulliyyah of Science, International Islamic University Malaysia (IIUM), Kuantan, Malaysia;Clinical Pharmacology Department, Menoufia Medical School, Menoufia University, Menoufia, Egypt;Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Kuantan, Malaysia;Department of Basic Medical Sciences, Kulliyyah of Nursing, International Islamic University Malaysia (IIUM), Kuantan, Malaysia;Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar;Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Kuantan, Malaysia;Department of Physiology, Faculty of Medicine, UKM Medical Centre (UKMMC), Kuala Lumpur, Malaysia;Neurology Unit, Department of Medicine, UKM Medical Centre (UKMMC), Kuala Lumpur, Malaysia;

关键词: zebrafish;    neurodegenerative diseases;    Parkinson’s disease;    dopaminergic neuron;    MPTP;    animal model;   

DOI  :  10.3389/fgene.2021.655550

来源: DOAJ

【 摘 要 】

The second most prevalent neurodegenerative disorder in the elderly is Parkinson’s disease (PD). Its etiology is unclear and there are no available disease-modifying medicines. Therefore, more evidence is required concerning its pathogenesis. The use of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the basis of most animal models of PD. MPTP is metabolized by monoamine oxidase B (MAO B) to MPP + and induces the loss of dopaminergic neurons in the substantia nigra in mammals. Zebrafish have been commonly used in developmental biology as a model organism, but owing to its perfect mix of properties, it is now emerging as a model for human diseases. Zebrafish (Danio rerio) are cheap and easy to sustain, evolve rapidly, breed transparent embryos in large amounts, and are readily manipulated by different methods, particularly genetic ones. Furthermore, zebrafish are vertebrate species and mammalian findings obtained from zebrafish may be more applicable than those derived from genetic models of invertebrates such as Drosophila melanogaster and Caenorhabditis elegans. The resemblance cannot be taken for granted, however. The goal of the present review article is to highlight the promise of zebrafish as a PD animal model. As its aminergic structures, MPTP mode of action, and PINK1 roles mimic those of mammalians, zebrafish seems to be a viable model for studying PD. The roles of zebrafish MAO, however, vary from those of the two types of MAO present in mammals. The benefits unique to zebrafish, such as the ability to perform large-scale genetic or drug screens, should be exploited in future experiments utilizing zebrafish PD models.

【 授权许可】

Unknown