New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities

Molecules

Duk-Yeon Cho¹  Dong-Kug Choi¹  PhanThi Hoai Trinh²  Jong-Soon Kang³  Hee-Jae Shin⁴  Byeoung-Kyu Choi⁴  Cao-Van Anh⁴  Hwa-Sun Lee⁴ 

[1] Department of Applied Life Science, Graduate school, BK21 Program, Konkuk University, Chungju 27478, Korea;Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 02 Hung Vuong, Nha Trang 650000, Vietnam;Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea;Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea;

关键词: Talaromyces cyanescens;    marine-derived fungus;    polyenes;    cytotoxicity;    anti-neuroinflammatory;   

DOI  :  10.3390/molecules26040836

来源: DOAJ

【 摘 要 】

Three new polyene compounds, talacyanols A–C (1–3), along with two known compounds, ramulosin (4) and eurothiocin A (5), were isolated from the marine fungus Talaromyces cyanescens derived from a seaweed Caulerpa sp. Structures of 1–5 were established by one-dimensional and two-dimensional (1D/2D) NMR, HR-ESIMS, and the modified Mosher’s methods, as well as comparison with previously reported literature data. All the compounds (1–5) were tested for their in vitro cytotoxic and anti-neuroinflammatory activities. Among them, 1 showed moderate cytotoxic activity against a panel of cancer cell lines (HCT-15, NUGC-3, NCI-H23, ACHN, PC-3, and MDA-MB-231) with GI₅₀ values ranging from 44.4 to 91.6 μM, whereas compounds 2 and 5 exhibited anti-neuroinflammatory effect without cytotoxicity against all the tested cell lines.

【 授权许可】

Unknown