Bone Marrow Failure Syndromes, Overlapping Diseases with a Common Cytokine Signature

International Journal of Molecular Sciences

Valentina Giudice¹  Massimo Triggiani¹  Carmine Selleri¹  Chiara Cardamone¹ 

[1] Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, 84081 Salerno, Italy;

关键词: cytokines;    bone marrow failure syndromes;    aplastic anemia;    myelodysplastic syndromes;   

DOI  :  10.3390/ijms22020705

来源: DOAJ

【 摘 要 】

Bone marrow failure (BMF) syndromes are a heterogenous group of non-malignant hematologic diseases characterized by single- or multi-lineage cytopenia(s) with either inherited or acquired pathogenesis. Aberrant T or B cells or innate immune responses are variously involved in the pathophysiology of BMF, and hematological improvement after standard immunosuppressive or anti-complement therapies is the main indirect evidence of the central role of the immune system in BMF development. As part of this immune derangement, pro-inflammatory cytokines play an important role in shaping the immune responses and in sustaining inflammation during marrow failure. In this review, we summarize current knowledge of cytokine signatures in BMF syndromes.

【 授权许可】

Unknown