期刊论文详细信息
Addiction Science & Clinical Practice
The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy
Carolyn Plater1  David C. Marsh1  Jeff Daiter1  Michael Varenbut1  Andrew Worster1  Guillaume Pare2  Zainab Samaan2  Lehana Thabane3  Leen Naji4  James MacKillop5  Dipika Desai6  Monica Bawor7  Brittany Burns Dennis7 
[1]Canadian Addiction Treatment Centres
[2]Department of Clinical Epidemiology and Biostatistics, McMaster University
[3]Departments of Pediatrics and Anesthesia, McMaster University
[4]Michael Degroote School of Medicine, McMaster University
[5]Peter Boris Centre for Addictions Research
[6]Population Genomic Program, Chanchalani Research Centre, McMaster University
[7]St. George’s University of London
关键词: Opioid use disorder;    Risk prediction;    Substance use;    Methadone;    Opioid substitution treatment;   
DOI  :  10.1186/s13722-017-0074-0
来源: DOAJ
【 摘 要 】
Abstract Background Opioid use disorder (OUD) affects approximately 21.9 million people worldwide. This study aims to determine the association between age of onset of opioid use and comorbid disorders, both physical and psychiatric, in patients receiving methadone maintenance treatment (MMT) for OUD. Understanding this association may inform clinical practice about important prognostic factors of patients on MMT, enabling clinicians to identify high-risk patients. Methods This study includes data collected between June 2011 and August 2016 for the Genetics of Opioid Addiction research collaborative between McMaster University and the Canadian Addiction Treatment Centers. All patients were interviewed by trained health professionals using the Mini-International Neuropsychiatric Interview and case report forms. Physical comorbidities were verified using patients’ electronic medical records. A multi-variable logistic regression model was constructed to determine the strength of the association between age of onset of opioid use and the presence of physical or psychiatric comorbidity while adjusting for current age, sex, body mass index, methadone dose and smoking status. Results Data from 627 MMT patients with a mean age of 38.8 years (SD = 11.07) were analyzed. Individuals with an age of onset of opioid use younger than 18 years were found to be at higher odds for having a physical or psychiatric comorbid disorder compared to individuals with an age of onset of opioid use of 31 years or older (odds ratio 2.94, 95% confidence interval 1.20, 7.19, p = 0.02). A significant association was not found between the risk of having a comorbidity and an age of onset of opioid use between 18 and 25 years or 26 and 30 years, compared to an age of onset of opioid use of 31 years or older. Conclusion Our study demonstrates that the younger one begins to use opioids, the greater their chance of having a physical or psychiatric co-morbidity. Understanding the risk posed by an earlier onset of opioid use for the later development of comorbid disorders informs clinical practice about important prognostic predictors and aids in the identification of high-risk patients.
【 授权许可】

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