Motor-related oscillatory activity in schizophrenia according to phase of illness and clinical symptom severity

NeuroImage: Clinical

Matthew J. Brookes¹  Jyothika Kumar²  Loes Koelewijn²  Peter G. Morris³  Zelekha A. Seedat⁴  James T.R. Walters⁴  Peter F. Liddle⁵  Mohammad Zia Ul Haq Katshu⁶  Gemma Williams⁶  Lena Palaniyappan⁶  J.F. William Deakin⁷  Mohanbabu Rathnaiah⁸  Krish D. Singh⁸  Lauren E. Gascoyne⁸ 

[1] Corresponding author at: Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University Park, Nottingham NG7 2RD, United Kingdom.;Nottinghamshire Healthcare NHS Foundation Trust, Nottingham NG3 6AA, United Kingdom;;Robarts Research Institute, University of Western Ontario &CUBRIC, School of Psychology, College of Biomedical and Life Sciences, Cardiff, Cardiff University CF24 4HQ, United Kingdom;;Department of Psychiatry &Institute of Mental Health, University of Nottingham, Jubilee Campus, Nottingham NG7 2TU, United Kingdom;MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, CF24 4HQ, United Kingdom;Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom;

关键词: Psychosis;    Schizophrenia;    Transient beta events;    Post-movement beta rebound;    Oscillatory bursts;   

DOI  :  

来源: DOAJ

【 摘 要 】

Magnetoencephalography (MEG) measures magnetic fields generated by synchronised neural current flow and provides direct inference on brain electrophysiology and connectivity, with high spatial and temporal resolution. The movement-related beta decrease (MRBD) and the post-movement beta rebound (PMBR) are well-characterised effects in magnetoencephalography (MEG), with the latter having been shown to relate to long-range network integrity. Our previous work has shown that the PMBR is diminished (relative to controls) in a group of schizophrenia patients. However, little is known about how this effect might differ in patients at different stages of illness and degrees of clinical severity. Here, we extend our previous findings showing that the MEG derived PMBR abnormality in schizophrenia exists in 29 recent-onset and 35 established cases (i.e., chronic patients), compared to 42 control cases. In established cases, PMBR is negatively correlated with severity of disorganization symptoms. Further, using a hidden Markov model analysis, we show that transient pan-spectral oscillatory ”bursts”, which underlie the PMBR, differ between healthy controls and patients. Results corroborate that PMBR is associated with disorganization of mental activity in schizophrenia.

【 授权许可】

Unknown