Effect of Nutrition Education in NAFLD Patients Undergoing Simultaneous Hyperlipidemia Pharmacotherapy: A Randomized Controlled Trial

Nutrients

Ji Eun Moon¹  Jea Hurn Bae²  Sang Gyune Kim³  Young Seok Kim³  Won Myung Lee³  Jeong-Ju Yoo³  Sae Hwan Lee⁴  Hong Soo Kim⁴  Soung Won Jeong⁵  Jae Young Jang⁵  Young Chang⁵ 

[1] Clinical Trial Center, Department of Biostatistics, SoonChunHyang University Bucheon Hospital, Bucheon 14584, Korea;Department of Food Science and Nutrition, SoonChunHyang University Bucheon Hospital, Bucheon 14584, Korea;Department of Internal Medicine, Digestive Disease Center and Research Institute, SoonChunHyang University School of Medicine, Bucheon 14584, Korea;Department of Internal Medicine, Division of Gastroenterology and Hepatology, SoonChunHyang University School of Medicine, Cheonan 31151, Korea;Department of Internal Medicine, Division of Gastroenterology and Hepatology, SoonChunHyang University School of Medicine, Seoul 04401, Korea;

关键词: non-alcoholic fatty liver disease;    hyperlipidemia;    health education;    nutrition;    nutrition education;   

DOI  :  10.3390/nu13124453

来源: DOAJ

【 摘 要 】

Background: Patients with non-alcoholic fatty liver disease (NAFLD) have a high prevalence of combined hyperlipidemia. The importance of nutritional education is well-known in NAFLD, but the impact of medical nutrition therapy (MNT) is unclear in patients with NAFLD with hyperlipidemia. The purpose of this study is to investigate the effect of MNT on the improvement of steatohepatitis in patients with NAFLD taking antihyperlipidemic medications. Methods: Nondiabetic patients with dyslipidemia were prospectively randomized (1:1) either to the MNT group or the control group with standard advice for 48 weeks with simultaneous statin/ezetimibe combination pharmacotherapy at three tertiary centers in Korea. Results: Sixty-six patients were enrolled. Among them, 18 patients dropped out and, overall, 48 patients (MNT group 27, control group 21) were prospectively analyzed in the study. The serum ALT level at 48 weeks between the two groups was not significantly different (66.6 ± 37.7 IU/L vs. 57.4 ± 36.7 IU/L, p = 0.40). Serum liver enzymes, controlled attenuation parameter and fibrosis-4 index were significantly improved within the MNT group after 48 weeks compared to baseline. There was no significant difference between the two groups other than the NAFLD fibrosis score (p = 0.017). Conclusions: Although there were no significant differences between the two groups in terms of steatosis, metabolic and fibrosis surrogate indicators after 48 weeks, MNT groups showed significant improvement within patient analysis over time. Future studies with a larger number of subjects and a longer study period regarding the effect of MNT are warranted.

【 授权许可】

Unknown