Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula

Marine Drugs

Fuhang Song¹  Xue Xiao²  Pratik Neupane²  Zeinab G. Khalil²  Angela A. Salim²  Robert J. Capon²  Paul V. Bernhardt³  Xiuli Xu⁴  Haijin Yang⁴  Liyuan Yin⁴ 

[1] CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia;School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia;School of Ocean Sciences, China University of Geosciences, Beijing 100083, China;

关键词: marine red alga;    Symphyocladia latiuscula;    bromophenols;    symphyocladins;    aconitates;   

DOI  :  10.3390/md15120374

来源: DOAJ

【 摘 要 】

This study describes an investigation into secondary metabolites that are produced by a marine red alga, Symphyocladia latiuscula, which was collected from coastal waters off Qingdao, China. A combination of normal, reversed phase, and gel chromatography was used to isolate six citric acid derived natural products, aconitates A–F (1–6), together with two known and ten new polybrominated phenols, symphyocladins C/D (7a/b), and symphyocladins H–Q (8a/b, 9a/b and 10–15), respectively. Structure elucidation was achieved by detailed spectroscopic (including X-ray crystallographic) analysis. We propose a plausible and convergent biosynthetic pathway involving a key quinone methide intermediate, linking aconitates and symphyocladins.

【 授权许可】

Unknown