Acute and cumulative effects of rTMS on behavioural and EMG parameters in Focal Hand Dystonia

Heliyon

Gennaro Boccia¹  Marcello Nobili²  Adriana Salatino²  Giulia Spadea³  Davide Dardanello³  Donato Formicola³  Anna Berti⁴ 

[1] Corresponding author.;Department of Psychology, University of Turin, Via Po 14, 10123, Italy;NeuroMuscularFunction Research Group, Department of Medical Sciences, University of Turin. 12, piazza Bernini, 10143, Torino, Italy;Unit of Neurology, Koelliker Hospital, Turin, Italy;

关键词: Neuroscience;    Behavioral neuroscience;    Muscle;    Neurology;    Nervous system;    Movement disorders;   

DOI  :  

来源: DOAJ

【 摘 要 】

Previous studies suggest that low-frequency repetitive Transcranial Magnetic Stimulation (rTMS) over contralateral premotor cortex (PMC) might ameliorate Focal Hand Dystonia (FHD) symptoms. In the present study behavioral and muscle activity outcomes were explored in a patient with FHD following a single and multiple sessions of rTMS. The patient's behavior was assessed on handwriting tasks, while surface EMG signals were recorded. In Experiment 1 evaluations were performed before and after one session of active and sham 1Hz rTMS over contralateral PMC. In Experiment 2, evaluations were performed before and after six sessions of the same treatment. In Experiment 1 active rTMS improved the patient's performance, although the EMG amplitude did not change. In Experiment 2, the patient showed an improvement of performance along with a decrease of 20% in the EMG amplitude. These results demonstrated that a single session of rTMS ameliorated the patient's performance, while multiple sessions were necessary to reduce muscles activity.

【 授权许可】

Unknown