Proportion and Characteristics of the Subjects with Low Muscle Mass and Abdominal Obesity among the Newly Diagnosed and Drug-Naïve Type 2 Diabetes Mellitus Patients

Diabetes & Metabolism Journal

Soon Young Hwang¹  Nam Hoon Kim²  Sin Gon Kim²  Ji A Seo³  Nan Hee Kim³  Jung A Kim⁴  Hye Soo Chung⁴  Sei Hyun Baik⁴  Kyung Mook Choi⁴  Hye Jin Yoo⁴ 

[1] Department of Biostatistics, Korea University College of Medicine, Seoul, .Korea;Division of Endocrinology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, .Korea;Division of Endocrinology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, .Korea;Division of Endocrinology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, .Korea;

关键词: Body composition;    Diabetes mellitus, type 2;    Insulin resistance;    Muscle, skeletal;    Obesity, abdominal;   

DOI  :  10.4093/dmj.2018.0036

来源: DOAJ

【 摘 要 】

BackgroundSarcopenic obesity (SO) is a serious public health concern, few studies have examined the clinical implications of SO in newly-diagnosed type 2 diabetes mellitus (T2DM) patients. We evaluated the prevalence of the newly diagnosed, drug-naïve T2DM patients with low muscle mass with abdominal obesity and its association with insulin resistance and other diabetic complications.MethodsWe classified 233 drug-naïve T2DM subjects into four groups according to abdominal obesity (waist circumference ≥90 cm in men and ≥85 cm in women) and low muscle mass status (appendicular skeletal muscle <7.0 kg/m2 for men and <5.4 kg/m2 for women).ResultsThe proportion of the subjects with low muscle mass and abdominal obesity among the newly diagnosed, drug-naïve T2DM patients was 8.2%. Homeostasis model assessment of insulin resistance (HOMA-IR) increased linearly according to body composition group from normal to abdominal obesity to both low muscle mass and abdominal obesity. The multiple logistic regression analysis indicated that subjects with low muscle mass and abdominal obesity (odds ratio [OR], 9.39; 95% confidence interval [CI], 2.41 to 36.56) showed a higher risk for insulin resistance, defined as HOMA-IR ≥3, than those with abdominal obesity (OR, 5.36; 95% CI, 2.46 to 11.69), even after adjusting for other covariates. However, there were no differences in lipid profiles, microalbuminuria, or various surrogate markers for atherosclerosis among the four groups.ConclusionSubjects with both low muscle mass and abdominal obesity had a higher risk of insulin resistance than those with low muscle mass or abdominal obesity only.

【 授权许可】

Unknown