期刊论文详细信息
International Journal of Environmental Research and Public Health
Comparison of Methodologies to Estimate Dietary Cadmium Intake in an Italian Population
Marco Vinceti1  Giorgia Adani1  Carlotta Malagoli1  Tommaso Filippini1  Claudia Baraldi2  Kristen Upson3  Bernhard Michalke4 
[1] CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center—Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy;Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy;Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA;Helmholtz Center Munich, German Research Center for Environmental Health GmbH, Research Unit Analytical BioGeoChemistry, 85764 Neuherberg, Germany;
关键词: cadmium;    food frequency questionnaire;    biomarker;    dietary intake;    estimation;   
DOI  :  10.3390/ijerph17072264
来源: DOAJ
【 摘 要 】

Cadmium is a metal that is toxic to humans, and the major source of cadmium exposure in the non-smoking general population is diet. To identify major food sources and lower exposure from diet, an accurate estimate of dietary cadmium intake is needed. Hence, the objectives of this study are to develop a method to assess dietary cadmium intake using a biomarker measurement and to improve the estimation of dietary cadmium intake when using a food frequency questionnaire (FFQ). In a random sample of an Italian population, we collected dietary habits by FFQ and measured cadmium in foods and beverages. These data were used to compute the estimated weekly dietary intake (WDI) of cadmium (µg) by kilogram (kg) of body weight (bw) (WDIFFQ). We also measured fasting serum cadmium levels by inductively-coupled plasma mass spectrometry. We used these data to develop a model for the estimation of the biomarker-derived dietary cadmium intake (WDIbio). In the 51 subjects recruited, the median level of serum cadmium was 0.041 µg/L (interquartile range (IQR): 0.030–0.054). The median WDIFFQ and WDIbio were 1.34 µg/kg bw/week (IQR: 0.86–1.70) and 0.72 µg/kg bw/week (IQR: 0.55–1.11), respectively. The correlation between the two estimates was low-to-moderate (r = 0.291). In exploratory analyses, the correlation was slightly higher in women and participants ages <50 years, and markedly higher in participants with body mass index <25 kg/m2 and smokers. Our approach allows for the dietary contribution to be isolated from the overall cadmium exposure measured with a biomarker; the estimated dietary cadmium intake was roughly similar to that estimated using the FFQ, especially in select subgroups. Future refinements to the biomarker-derived dietary cadmium intake approach should take into consideration additional sources of cadmium exposure, as well as factors affecting its absorption and metabolism.

【 授权许可】

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