Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study

Life

Carmelo Pirri¹  Lucia Petrelli¹  Caterina Fede¹  Carla Stecco¹  Chenglei Fan¹  Raffaele De Caro¹  Pietro Ruggieri²  Carlo Biz²  Ilaria Fantoni² 

[1] Department of Neurosciences, Institute of Human Anatomy, University of Padua, 35121 Padua, Italy;Orthopedics and Orthopedic Oncology, Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, 35128 Padua, Italy;

关键词: fascia;    hip osteoarthritis;    hyaluronan;    collagen;    stiffness;    myofascial pain;   

DOI  :  10.3390/life11111136

来源: DOAJ

【 摘 要 】

The present study compares the structure and composition of fascia lata in healthy subjects and in patients with hip osteoarthritis (OA), to evaluate any differences in the amount of Collagen type I, Collagen type III, and Hyaluronan. Fascia lata samples from voluntary healthy subjects and patients with OA were harvested during surgery. Collagen type I (COL I), III (COL III) antibody, and biotinylated hyaluronan binding protein (HABP) immunohistochemistry stainings were used to evaluate fascial morphology and COL I, COL III, and Hyaluronan (HA) content in both groups. Ten samples from healthy subjects and 11 samples from OA patients were collected. COL I was significantly more abundant in the OA group (p = 0.0015), with a median percentage positivity of 75.2 (IQR 13.11)%, while representing only 67 (IQR: 8.71)% in control cases. COL III, with median values of 9.5 (IQR 3.63)% (OA group) and 17.10 (IQR 11)% (control cases), respectively, showed significant reduction in OA patients (p = 0.002). HA showed a median value of 10.01 (IQR 8.11)% in OA patients, denoting significant decrease (p < 0.0001) with respect to the control group median 39.31 (IQR 5.62)%. The observed differences suggest a relationship between fascial pathology and hip OA. The observed increase in COL I in OA patients, along with the reduction of COL III and HA, could lead to fascial stiffening, which could alter fascial mechanics and be linked to the development and symptoms of OA.

【 授权许可】

Unknown