Comparison of Unsatisfactory Samples from Conventional Smear versus Liquid-Based Cytology in Uterine Cervical Cancer Screening Test

Journal of Pathology and Translational Medicine

Sung Ran Hong¹  Sung-chul Lim²  Eun Kyung Kim³  Sun Hee Sung⁴  Hye Kyoung Yoon⁵  Seoung-Wan Chae⁶  Juhie Lee⁷  So-Young Jin⁸  Eun-Jung Park⁹  Jong Jae Jung⁹  Sung Nam Kim^1,10  Sook Tai Ha^1,11 

[1] Department of Pathology, Cheil General Hospital and Women’s Health Care Center, Dankook University College of Medicine, Seoul, Korea;Department of Pathology, Chosun University School of Medicine, Gwangju, Korea;Department of Pathology, Eulji General Hospital, Seoul, Korea;Department of Pathology, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Korea;Department of Pathology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea;Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea;Department of Pathology, Kyung Hee University School of Medicine, Seoul, Korea;Department of Pathology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea;Foryou Pathology Laboratories, Gwangju, Korea;Samkwang Medical Laboratories, Seoul, Korea;T&C Diagnostic Pathology Clinic, Seoul, Korea;

关键词: Papanicolaou test;    Cervical cytology;    Unsatisfactory;    Liquid-based cytology;    Conventional smear;   

DOI  :  10.4132/jptm.2017.03.17

来源: DOAJ

【 摘 要 】

Background Cervical cytology for uterine cervical cancer screening has transitioned from conventional smear (CS) to liquid-based cytology (LBC), which has many advantages. The aim of this study was to compare the proportion of unsatisfactory specimens from CS versus LBC at multiple institutions including general hospitals and commercial laboratories. Methods Each participating institution provided a minimum of 500 Papanicolaou (Pap) test results for analysis. Pap tests were classified according to the participating institution (commercial laboratory or general hospital) and the processing method (CS, ThinPrep, SurePath, or CellPrep). The causes of unsatisfactory results were classified as technical problems, scant cellularity, or complete obscuring factors. Results A total of 38,956 Pap test results from eight general hospitals and three commercial laboratories were analyzed. The mean unsatisfactory rate of LBC was significantly lower than that of CS (1.26% and 3.31%, p = .018). In the LBC method, samples from general hospitals had lower unsatisfactory rates than those from commercial laboratories (0.65% vs 2.89%, p = .006). The reasons for unsatisfactory results were heterogeneous in CS. On the other hand, 66.2% of unsatisfactory results in LBC were due to the scant cellularity. Conclusions Unsatisfactory rate of cervical cancer screening test results varies according to the institution and the processing method. LBC has a significantly lower unsatisfactory rate than CS.

【 授权许可】

Unknown