The Role of VP16 in the Life Cycle of Alphaherpesviruses

Frontiers in Microbiology

Ying Wu¹  Mafeng Liu¹  Bin Tian¹  Mingshu Wang¹  Shaqiu Zhang¹  Xiaoyue Chen¹  Qun Gao¹  Ling Zhang¹  Shun Chen¹  Anchun Cheng¹  Dengjian Fan¹  Xumin Ou¹  Qiao Yang¹  Di Sun¹  Xingjian Wen¹  Yunya Liu¹  Leichang Pan¹  Sai Mao¹  Xinxin Zhao¹  Dekang Zhu¹  Yanling Yu¹  Renyong Jia¹ 

[1] Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China;Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China;Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, China;

关键词: alphaherpesvirus;    VP16;    transcriptional activation;    secondary envelopment;    reactivation from latency;   

DOI  :  10.3389/fmicb.2020.01910

来源: DOAJ

【 摘 要 】

The protein encoded by the UL48 gene of alphaherpesviruses is named VP16 or alpha-gene-transactivating factor (α-TIF). In the early stage of viral replication, VP16 is an important transactivator that can activate the transcription of viral immediate-early genes, and in the late stage of viral replication, VP16, as a tegument, is involved in viral assembly. This review will explain the mechanism of VP16 acting as α-TIF to activate the transcription of viral immediate-early genes, its role in the transition from viral latency to reactivation, and its effects on viral assembly and maturation. In addition, this review also provides new insights for further research on the life cycle of alphaherpesviruses and the role of VP16 in the viral life cycle.

【 授权许可】

Unknown