Phenotype Definition for “Resisters” to Mycobacterium tuberculosis Infection in the Literature—A Review and Recommendations

Frontiers in Immunology

Marlo Möller¹  Elouise E. Kroon¹  Jesús Gutierrez²  Catherine M. Stein² 

[1] DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa;Department of Population and Quantitative Health Science, Case Western Reserve University School of Medicine, Cleveland, OH, United States;

关键词: tuberculosis;    resister;    phenotype;    tuberculin skin test;    interferon-γ release assay;    review;   

DOI  :  10.3389/fimmu.2021.619988

来源: DOAJ

【 摘 要 】

Tuberculosis (TB) remains a worldwide problem. Despite the high disease rate, not all who are infected with Mycobacterium Tuberculosis (Mtb) develop disease. Interferon-γ (IFN-γ) specific T cell immune assays such as Quantiferon and Elispot, as well as a skin hypersensitivity test, known as a tuberculin skin test, are widely used to infer infection. These assays measure immune conversion in response to Mtb. Some individuals measure persistently negative to immune conversion, despite high and prolonged exposure to Mtb. Increasing interest into this phenotype has led to multiple publications describing various aspects of these responses. However, there is a lack of a unified “resister” definition. A universal definition will improve cross study data comparisons and assist with future study design and planning. We review the current literature describing this phenotype and make recommendations for future studies.

【 授权许可】

Unknown