Neuroticism Modulates the Functional Connectivity From Amygdala to Frontal Networks in Females When Avoiding Emotional Negative Pictures

Frontiers in Behavioral Neuroscience

Martin Walter¹  Yaling Deng⁶  Shijia Li⁷  Renlai Zhou⁸ 

[1] Department for Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany;Department of Psychiatry and Psychotherapy, Eberhard Karls University, Tübingen, Germany;Department of Psychology, School of Social and Behavior Sciences, Nanjing University, Nanjing, China;;Key Laboratory of Brain Functional Genomics (MOE&Max Planck Institute for Biological Cybernetics, Tübingen, Germany;Neuroscience and Intelligent Media Institute, Communication University of China, Beijing, China;STCSM), Shanghai Changning-ECNU Mental Health Center, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China;Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China;

关键词: functional connectivity;    neuroticism;    motivational direction;    dorsomedial prefrontal cortex;    middle cingulate cortex;   

DOI  :  10.3389/fnbeh.2019.00102

来源: DOAJ

【 摘 要 】

Amygdala activity was previously found to correlate with neuroticism as an effect of valence, but so far few studies have focused on motivational context. The network subserving altered amygdala activity has not yet been investigated although some studies showed strong effective connections with prefrontal cortex (PFC). The goal of this study was to test the modulatory role of neuroticism on the functional connectivity (FC) between amygdala and other brain regions, especially PFC, during emotion processing from motivational direction. We applied an emotional picture viewing paradigm with different motivational directions (approaching and avoiding) in a large participant sample. The results showed that neuroticism predicted the amount of amygdala FC to dorsomedial PFC (dmPFC) and middle cingulate cortex (MCC). Increased FC during negative vs. positive pictures was found primarily in low neuroticism subjects, especially during the avoid condition. This valence and motivation dependent connectivity increase were disrupted for high neurotic participants. No effect of neuroticism was found for the approach condition. We showed that neuroticism, especially in the context of passive affect regulation, may have impaired connectivity between amygdala and putative regulatory cortical networks.

【 授权许可】

Unknown