Urease Levels and Gastritis Stage in Dyspeptic Patients

Acta Medica Indonesiana

Yoshio Yamaoka¹  Muhammad Miftahussurur²  Yudith Annisa Ayu Rezkitha³  Hartono Kahar⁴  Reny I’tishom⁵  Tomohisa Uchida⁶  Gontar Alamsyah Siregar⁷  Husin Thamrin⁸  Amie Vidyani⁸  Herry Purbayu⁸  Poernomo Boedi Setiawan⁸  Ummi Maimunah⁸  Iswan Abbas Nusi⁸  Ulfa Kholili⁸  Titong Sugihartono⁸  Budi Widodo⁸  Chyntia Dewi Maharani Putri⁸  Ari Fahrial Syam⁹  Diah Priyantini^1,10  Langgeng Agung Waskito^1,11 

[1] 1. Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia2. Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Japan;1. Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia 2. Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia3. Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Japan;1. Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia2. Faculty of Medicine, Muhammadiyah University of Surabaya, Surabaya 60113, Indonesia;Department of Clinical Pathology, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60131, Indonesia;Department of Medical Biology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia;Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu 879-5593, Japan;Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, North Sumatra University, Medan, 20115, Indonesia;Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia;Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia;Faculty of Nursing, Universitas Airlangga, Surabaya 60115, Indonesia;Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia;

关键词: dyspepsia;    gastritis severity;    urea breath test;    cancer;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Dyspepsia is a frequent main symptom of inpatients and outpatients scenario in Indonesia. However, the number of endoscopy facilities are still low, thus the use of non-invasive method to detect gastritis is necessary. We measured the relationship between urease levels and the stage of gastritis in dyspeptic adult patients. Methods: A cross-sectional study included outpatient dyspepsia patient from November 2018 to February 2019. We examined 14C-Urea Breath Test (UBT) and determined the stage of gastritis based on the Updated Sydney System classification. Results: The urease level of acute and chronic gastritis positive patients were higher than negative patients (p = 0.001, r = 0.353; p <0.0001, r = 0.433, respectively). The AUC value of 14C-UBT to detect acute, chronic, and atrophic gastritis are 0.889, 0.632 and 0.544, respectively. The best cut-off points of 14C-UBT to predict acute gastritis was ≥26.50δ‰ with sensitivity and specificity being 88.89% and 63.95%, respectively. Whereas the best cut-off points for chronic gastritis was ≥34.50δ‰ with 82.89% sensitivity, 63.16% specificity. As for atrophic gastritis, it showed very low AUC value, hence it is not a sufficient test modality to predict atrophic gastritis cases. Conclusion: 14C-UBT is sufficient for predicting acute or chronic gastritis but not for atrophic gastritis.

【 授权许可】

Unknown