Heliyon | |
Aberrant timing and oddball detection in Schizophrenia: findings from a signed differential mapping meta-analysis | |
Aleix Solanes1  Patricio Molero2  María Sol Garcés3  Irene Alústiza4  Javier Goena4  Joaquim Radua4  Felipe Ortuño4  Marta Ortuño5  | |
[1] Corresponding author.;FIDMAG Germanes Hospitalaries, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Saint Boi de Llobregat, Barcelona, Spain;Instituto de Investigación Sanitaria de Navarra (IDISNA), Navarra, Spain;Department of Psychiatry and Clinical Psychology, Clínica Universidad de Navarra, Pamplona, Navarra, Spain;Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain; | |
关键词: Clinical psychology; Psychiatry; Neuroscience; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
Schizophrenia (SZ) is associated with deficits in both temporal and salience processing. The underlying neurological dysfunctions in both processes, which are interrelated and share neuroanatomical bases, remain poorly understood. The principal objective of this study was to elucidate whether there are any brain regions that show abnormal response during timing and oddball tasks in patients with SZ. To this end, we conducted a signed differential mapping (SDM) meta-analysis of functional magnetic resonance imaging (fMRI) studies assessing abnormal responses elicited by tasks based on the oddball paradigm in patients with SZ. We conducted a similar SDM meta-analysis of neuroimaging studies of timing tasks in SZ. Finally, we undertook a multimodal meta-analysis to detect the common findings of the two previous meta-analyses. We found that SZ patients showed hypoactivation in cortical and subcortical areas related to timing. The dysfunction observed during timing tasks partially coincided with deficiencies in change-detection functions (particularly in the case of preattentional processing in the mismatch negativity response). We hypothesize that a dysfunctional timing/change detection network underlies the cognitive impairment observed in SZ.
【 授权许可】
Unknown