Chemical Conjugation Strategies for the Development of Protein-Based Subunit Nanovaccines

Vaccines

Ahmed O. Shalash¹  Mariusz Skwarczynski¹  Lantian Lu¹  Istvan Toth¹  Viet Tram Duong¹ 

[1] School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia;

关键词: conjugation strategies;    protein subunit vaccines;    nanovaccines;    vaccine delivery;    nanoparticulate delivery systems;   

DOI  :  10.3390/vaccines9060563

来源: DOAJ

【 摘 要 】

The production of subunit nanovaccines relies heavily on the development of a vaccine delivery system that is safe and efficient at delivering antigens to the target site. Nanoparticles have been extensively investigated for vaccine delivery over the years, as they often possess self-adjuvanting properties. The conjugation of antigens to nanoparticles by covalent bonds ensures co-delivery of these components to the same subset of immune cells in order to trigger the desired immune responses. Herein, we review covalent conjugation strategies for grafting protein or peptide antigens onto other molecules or nanoparticles to obtain subunit nanovaccines. We also discuss the advantages of chemical conjugation in developing these vaccines.

【 授权许可】

Unknown