Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico

Emerging Infectious Diseases

关键词: West Nile virus;    arbovirus;    flavivirus;    Mexico;    genome sequence;    dispatch;   

DOI  :  10.3201/eid1012.040647

来源: DOAJ

【 摘 要 】

The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.

【 授权许可】

Unknown