New strategies for diagnosis and treatment of hepatitis B virus-related liver failure

Linchuang Gandanbing Zazhi

GAO Zhiliang¹  YANG Fangji¹  PENG Liang¹ 

[1] Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University;

关键词: liver failure;    hepatitis B virus;    diagnosis;    therapy;    review;   

DOI  :  10.3969/j.issn.1001-5256.2017.03.041

来源: DOAJ

【 摘 要 】

Hepatitis B virus (HBV)-related liver failure has an extremely high mortality rate and a complex pathogenesis, and since related mechanisms are not fully understood, it has been very difficult to diagnose and treat this disease in clinical practice. Apart from liver transplantation, there is still a lack of specific and effective drugs and therapies for the medical treatment of HBV-related liver failure. This article summarizes our experience and research achievements in the diagnosis and treatment of HBV-related liver failure, explores the association between host’s genetic background and development and aggravation of chronic hepatitis B, and elaborates on the phenomenon of “three attacks” and the concept of “four time phases”. In the aspect of treatment, this article focuses on the clinical application of antiviral therapy, anti-infective therapy, glucocorticoids, and stem cell transplantation; for the evaluation of patients’ condition, this article establishes a suitable system for evaluating the prognosis of HBV-related liver failure.

【 授权许可】

Unknown