Sleep deprivation alters task‐related changes in functional connectivity of the frontal cortex: A near‐infrared spectroscopy study

Brain and Behavior

Frigyes Samuel Racz¹  Orestis Stylianou¹  Farzaneh A. Sorond²  György Purebl³  Andriy Yabluchanskiy⁴  Stefano Tarantini⁴  Tamas Csipo⁴  Jonathan W. Perry⁴  Anna Csiszar⁴  Zoltan I. Ungvari⁴  Peter Mukli⁴  Agnes Lipecz⁴  Cameron D. Owens⁴  Jeremy M. Kellawan⁴  William E. Sonntag⁴  Yuan Yang⁵ 

[1] Department of Physiology Faculty of Medicine Semmelweis University Budapest Hungary;Division of Stroke and Neurocritical Care Department of Neurology Northwestern University Feinberg School of Medicine Chicago IL USA;Institute of Behavioral Sciences Semmelweis University Budapest Hungary;Oklahoma Center for Geroscience and Healthy Brain Aging Department of Biochemistry and Molecular Biology University of Oklahoma Health Sciences Center Oklahoma City OK USA;Stephenson School of Biomedical Engineering The University of Oklahoma Tulsa OK USA;

关键词: functional connectivity;    near‐infrared;    neuropsychological tests;    sleep deprivation;    spectroscopy;   

DOI  :  10.1002/brb3.2135

来源: DOAJ

【 摘 要 】

Abstract Sleep deprivation (SD) is known to be associated with decreased cognitive performance; however, the underlying mechanisms are poorly understood. As interactions between distinct brain regions depend on mental state, functional brain networks established by these connections typically show a reorganization during task. Hence, analysis of functional connectivity (FC) could reveal the task‐related change in the examined frontal brain networks. Our objective was to assess the impact of SD on static FC in the prefrontal and motor cortices and find whether changes in FC correlate with changes in neuropsychological scores. Healthy young male individuals (n = 10, 27.6 ± 3.7 years of age) participated in the study. A battery of tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) and 48 channel functional near‐infrared spectroscopy (fNIRS) measurements were performed before and after 24 hr of SD. Network metrics were obtained by graph theoretical analysis using the fNIRS records in resting state and during finger‐tapping sessions. During task, SD resulted in a significantly smaller decrease in the number and strength of functional connections (characterizing FC) in the frontal cortex. Changes in the global connection strengths correlated with decreased performance in the paired association learning test. These results indicate a global impact of SD on functional brain networks in the frontal lobes.

【 授权许可】

Unknown