Mast Cells as the Target of the Biological Effects of Molecular Hydrogen in the Specific Tissue Microenvironment

International Journal of Biomedicine

Tatiana V. Samoilenko¹  Lyubov N. Antakova¹  Olga A. Gerasimova¹  Pavel Yu. Andreev¹  Evgeniy S. Ovsyannikov¹  Victoria V. Shishkina¹  Dmitry I. Esaulenko¹  Dmitry A. Atiakshin¹  Sara T. Magerramova¹  Sofia A. Budnevskaya¹ 

[1] Voronezh state medical university named after N.N. Burdenko, Voronezh, Russia;

关键词: mast cell;    tryptase;    chymase;    specific tissue microenvironment;    molecular hydrogen;   

DOI  :  10.21103/Article12(2)_RA2

来源: DOAJ

【 摘 要 】

Mast cells (MCs) as key players in the development of both physiological and pathological processes in the organism can form a specific tissue microenvironment. Having a rich secretion of biologically active substances, MCs can secrete tryptase and/or chymase and thereby participate in the regulation of processes such as inflammation, neoangiogenesis, allergic reactions, and oncogenesis. Reactive oxygen intermediates (ROI) play an essential role in regulation of MC degranulation, shown in vitro and in vivo models. Application of molecular hydrogen as a substance with antioxidant characteristics pathogenically appears to be an important mechanism decreasing MC secretory activity, and, as a consequence, a novel option to reduce an inflammatory background in the specific tissue microenvironment.

【 授权许可】

Unknown