Clinical Validation of a Pixon-Based Reconstruction Method Allowing a Twofold Reduction in Planar Images Time of 111In-Pentetreotide Somatostatin Receptor Scintigraphy

Frontiers in Medicine

Philippe Thuillier¹  Philippe Chaumet-Riffaud³  Ulrike Schick⁴  Véronique Kerlan⁵  Pierre-Yves Le Roux⁵  David Bourhis⁵  Nathalie Keromnes⁵  Philippe Robin⁵  Ronan Abgral⁵  Pierre-Yves Salaün⁵ 

[1] Department of Endocrinology, University Hospital of Brest, Brest, France;Department of Nuclear Medicine, University Hospital of Brest, Brest, France;Department of Nuclear Medicine, University Hospital of Paris-Sud Bicêtre, Le Kremlin-Bicêtre, France;Department of Oncology-Radiotherapy, University Hospital of Brest, Brest, France;EA GETBO 3878, IFR 148, University Hospital of Brest, Brest, France;

关键词: signal and image processing;    Pixon-based method;    somatostatin receptor scintigraphy;    planar images;    half time acquisition;   

DOI  :  10.3389/fmed.2017.00143

来源: DOAJ

【 摘 要 】

ObjectiveThe objective of this study was to evaluate the diagnostic efficacy of Pixon-based reconstruction method on planar somatostatin receptor scintigraphy (SRS).MethodsAll patients with neuroendocrine tumors (NETs) disease who were referred for SRS to our department during 1-year period from January to December 2015 were consecutively included. Three nuclear physicians independently reviewed all the data sets of images which included conventional images (CI; 15 min/view) and processed images (PI) obtained by reconstructing the first 450 s extracted data using Oncoflash® software package. Image analysis using a 3-point rating scale for abnormal uptake of 111 Indium-DTPA-Phe-octreotide in any lesion or organ was interpreted as positive, uncertain, or negative for the evidence of NET disease. A maximum grade uptake of the radiotracer in the lesion was assessed by the Krenning scale method. The results of image interpretation by the two methods were considered significantly discordant when the difference in organ involvement assessment was negative vs. positive or in lesion uptake was ≥2 grades. Agreement between the results of two methods and by different scan observers was evaluated using Cohen κ coefficients.ResultsThere was no significant (p = 0.403) correlation between data acquisition protocol and quality image. The rates of significant discrepancies for exam interpretation and organs involvement assessment were 2.8 and 2.6%, respectively. Mean κ values revealed a good agreement for concordance between CI and PI interpretation without difference of agreement for inter/intra-observer analysis.ConclusionOur results suggest the feasibility to use a Pixon-based reconstruction method for SRS planar images allowing a twofold reduction of acquisition time and without significant alteration of image quality or on image interpretation.

【 授权许可】

Unknown