Implant Surfaces Containing Bioglasses and Ciprofloxacin as Platforms for Bone Repair and Improved Resistance to Microbial Colonization

Pharmaceutics

Miruna Silvia Stan¹  Mariana Carmen Chifiriuc¹  Marcela Popa²  Luminita Marutescu²  Irina Negut³  Ion N. Mihailescu³  Carmen Ristoscu³  Tatiana Tozar³  Claudiu Hapenciuc³  Valentina Grumezescu³  Anca Constantina Parau⁴  Mihaela Dinu⁴ 

[1] Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania;Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 077206 Bucharest, Romania;National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, 077125 Magurele, Romania;National Institute of Research and Development for Optoelectronics-INOE2000, 409 Atomistilor St., 077125 Magurele, Romania;

关键词: thin film;    antibiotic delivery;    biocompatibility;    bioglass;    laser deposition;   

DOI  :  10.3390/pharmaceutics14061175

来源: DOAJ

【 摘 要 】

Coatings are an attractive and challenging selection for improving the bioperformance of metallic devices. Composite materials based on bioglass/antibiotic/polymer are herein proposed as multifunctional thin films for hard tissue implants. We deposited a thin layer of the polymeric material by matrix-assisted pulsed laser evaporation—MAPLE onto Ti substrates. A second layer consisting of bioglass + antibiotic was applied by MAPLE onto the initial thin film. The antimicrobial activity of MAPLE-deposited thin films was evaluated on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa standard strains. The biocompatibility of obtained thin films was assessed on mouse osteoblast-like cells. The results of our study revealed that the laser-deposited coatings are biocompatible and resistant to microbial colonization and biofilm formation. Accordingly, they can be considered viable candidates for biomedical devices and contact surfaces that would otherwise be amenable to contact transmission.

【 授权许可】

Unknown