Detection of paraprotein in plasma cell tumors

Терапевтический архив

Natalia P. Soboleva¹  Irina G. Rekhtina¹  Larisa P. Mendeleeva¹  Irina A. Dubina²  Margarita Iu. Pervakova²  Sergey V. Lapin² 

[1] National Medical Research Center for Hematology;Pavlov First Saint Petersburg State Medical University;

关键词: paraprotein;    multiple myeloma;    plasma cell disease;   

DOI  :  10.26442/10.26442/00403660.2022.01.201326

来源: DOAJ

【 摘 要 】

Paraprotein is a laboratory biomarker of plasma cell tumors and other lymphoproliferative diseases. Its determination is necessary for diagnosing, monitoring and assessment of therapy effectiveness. The lecture presents the main methods of qualitative and quantative analysis of monoclonal proteins: gel electrophoresis, capillary electrophoresis, immunofixation and nephelometry features, possibilities and limitations are reviewed. The main sources of errors and artifacts during these studies are considered. Also the difficulties in the diagnosis and interpretation of the results of serum and urine tests are highlighted.

【 授权许可】

Unknown