Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome

Emerging Infectious Diseases

关键词: Middle East respiratory syndrome;    MERS;    coronavirus;    CoV;    coronavirus infections;    acute respiratory distress syndrome;   

DOI  :  10.3201/eid2606.200037

来源: DOAJ

【 摘 要 】

Available animal and cell line models have suggested that specific therapeutics might be effective in treating Middle East respiratory syndrome (MERS). We conducted a systematic review of evidence for treatment with pharmacologic and supportive therapies. We developed a protocol and searched 5 databases for studies describing treatment of MERS and deaths in MERS patients. Risk of bias (RoB) was assessed by using ROBINS-I tool. We retrieved 3,660 unique citations; 20 observational studies met eligibility, and we studied 13 therapies. Most studies were at serious or critical RoB; no studies were at low RoB. One study, at moderate RoB, showed reduced mortality rates in severe MERS patients with extracorporeal membrane oxygenation; no other studies showed a significant lifesaving benefit to any treatment. The existing literature on treatments for MERS is observational and at moderate to critical RoB. Clinical trials are needed to guide treatment decisions.

【 授权许可】

Unknown