Combined pharmacological and motor training interventions for recovery of upper limb function in subacute ischemic stroke

Balneo Research Journal

Adriana Bulboaca¹  Ioana Stanescu²  Alina Blesneag²  Delia Stanca²  Adina Stan²  Gabriela Dogaru³  Rita Kallo⁴ 

[1] Dep. of Physiopathology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj Napoca;Depart. of Clinical Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj Napoca;Depart. of Physical Med. and Rehab., “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj Napoca;Rehabilitation Hospital Cluj Napoca;

关键词: stroke rehabilitation;    neural plasticity;    Cerebrolysin;    motor recovery;   

DOI  :  10.12680/balneo.2017.145

来源: DOAJ

【 摘 要 】

Motor deficit, especially in the upper limb, is the primary contributor in post-stroke disability. Recovery of motor function relies on neural plasticity – cortical plastic reorganization – a spontaneous process, which could be enhanced from early phases by rehabilitative strategies. The subacute stage after stroke is the critical period during which the brain is most receptive to rehabilitation strategies. Based on the recent results of 2 trials in stroke rehabilitation using pharmacological intervention with Cerebrolysin in combination with standardized kinesitherapy, we conducted a pilot study of 4 consecutive patients with acute ischemic stroke, treated with Cerebrolysin for 28 days after stroke, and with intensive task-specific kinesitherapy from day 7 to day 28 after stroke. We assessed stroke severity with NIHSS score, upper limb function with ARAT (Action Research Arm Test) score, disability with modified Rankin scale and patient’s autonomy with Barthel Index, at day 0 and day 30 after stroke. After 28 days of combined therapy all 4 patients improved, most significant improvement was seen in upper limb function, measured by ARAT score and in autonomy measured by Barthel Index.

【 授权许可】

Unknown