Determining Response to Treatment for Drug-Induced Bronchocentric Granulomatosis by the Forced Oscillation Technique

Medicina

Noboru Takamura¹  Kazuto Ashizawa²  Junya Fukuoka³  Mutsumi Ozasa³  Yoshiaki Zaizen³  Susumu Fukahori⁴  Jun Iriki⁴  Chizu Fukushima⁴  Hiroshi Mukae⁴  Daisuke Takao⁴  Yasushi Obase⁴ 

[1] Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan;Department of Clinical Oncology, Graduate School of Biomedical Sciences, Nagasaki University 1-7-1 Sakamoto, Nagasaki 852-8501, Japan;Department of Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan;Department of Respiratory Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan;

关键词: forced oscillation technique;    small airway disease;    anti-tumor necrosis factor alpha therapy;    sarcoid-like reaction;    bronchocentric granulomatosis;    ulcerative colitis;   

DOI  :  10.3390/medicina57121315

来源: DOAJ

【 摘 要 】

Anti-tumor necrosis factor alpha (TNFα) therapy is widely used to treat various inflammatory conditions. Paradoxically, there are several case reports describing the development of bronchocentric granulomatosis treated with TNFα inhibitors, and it is difficult to determine the effect of treatment using conventional spirometry because the lesions are located in small airways. However, it has been reported that the forced oscillation technique (FOT) is useful in the evaluation of small airway disease in bronchial asthma or chronic obstructive pulmonary disease. We performed the FOT to determine the effect of treatment on bronchocentric granulomatosis and found it to be useful. We report the case of a 55-year-old female with ulcerative colitis who was treated with golimumab and who developed bronchocentric granulomatosis as a sarcoid-like reaction to golimumab. She was successfully treated with prednisone, and the treatment efficacy was confirmed by the FOT. The FOT may be useful in the evaluation of small airway disease in bronchocentric granulomatosis. This case may help inform clinicians of the usefulness of the FOT to assess small airway disease in various diseases.

【 授权许可】

Unknown