In vitro degradation and surface bioactivity of iron-matrix composites containing silicate-based bioceramic

Bioactive Materials

Jie Zhou¹  Haiyan Li²  Yachen Xu²  Jiang Chang³  Sanguo Wang³  Zhiguang Huan³ 

[1] Department of Biomechanical Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands;Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China;Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, China;

关键词: Iron;    Calcium silicate;    Composite;    Biodegradation;    Bioactivity;    Implant;   

DOI  :  10.1016/j.bioactmat.2016.12.001

来源: DOAJ

【 摘 要 】

Iron-matrix composites with calcium silicate (CS) bioceramic as the reinforcing phase were fabricated through powder metallurgy processes. The microstructures, mechanical properties, apatite deposition and biodegradation behavior of the Fe-CS composites, as well as cell attachment and proliferation on their surfaces, were characterized. In the range of CS weight percentages selected in this study, the composites possessed compact structures and showed differently decreased bending strengths as compared with pure iron. Immersion tests in simulated body fluid (SBF) revealed substantially enhanced deposition of CaP on the surfaces of the composites as well as enhanced degradation rates as compared with pure iron. In addition, the composite containing 20% CS showed a superior ability to stimulate hBMSCs proliferation when compared to pure iron. Our results suggest that incorporating calcium silicate particles into iron could be an effective approach to developing iron-based biodegradable bone implants with improved biomedical performance.

【 授权许可】

Unknown