High-frequency and brief-pulse stimulation pulses terminate cortical electrical stimulation-induced afterdischarges

Neural Regeneration Research

关键词: nerve regeneration;    cortical electrical stimulation;    afterdischarges;    intractable epilepsy;    functional brain mapping;    high frequency stimulation;    low frequency stimulation;    neuromodulation;    neural regeneration;   

DOI  :  10.4103/1673-5374.208576

来源: DOAJ

【 摘 要 】

Brief-pulse stimulation at 50 Hz has been shown to terminate afterdischarges observed in epilepsy patients. However, the optimal pulse stimulation parameters for terminating cortical electrical stimulation-induced afterdischarges remain unclear. In the present study, we examined the effects of different brief-pulse stimulation frequencies (5, 50 and 100 Hz) on cortical electrical stimulation-induced afterdischarges in 10 patients with refractory epilepsy. Results demonstrated that brief-pulse stimulation could terminate cortical electrical stimulation-induced afterdischarges in refractory epilepsy patients. In conclusion, (1) a brief-pulse stimulation was more effective when the afterdischarge did not extend to the surrounding brain area. (2) A higher brief-pulse stimulation frequency (especially 100 Hz) was more likely to terminate an afterdischarge. (3) A low current intensity of brief-pulse stimulation was more likely to terminate an afterdischarge

【 授权许可】

Unknown