Determinants of Increased Serum Calprotectin in Patients with Type 2 Diabetes Mellitus

International Journal of Molecular Sciences

Gerjan Navis¹  StephanJ.L. Bakker¹  MilouM. Oosterwijk²  GozewijnD. Laverman²  Tom Nilsen³ 

[1] Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands;Department of Internal Medicine/Nephrology, Ziekenhuis Groep Twente, Zilvermeeuw 1, 7609 PP Almelo, The Netherlands;Gentian Diagnostics AS, Bjornasveien 5, 1596 Moss, Norway;

关键词: calprotectin;    type 2 diabetes mellitus;    cardiovascular diseases;    lifestyle;    smoking;    biomarker;   

DOI  :  10.3390/ijms21218075

来源: DOAJ

【 摘 要 】

Circulating calprotectin is a potential biomarker for endovascular inflammation in type 2 diabetes mellitus (T2DM). We investigated the determinants of calprotectin and its relationship with the presence of cardiovascular disease (CVD) in 362 T2DM patients included in the Diabetes and Lifestyle Cohort Twente-1 (DIALECT-1) study. Lifestyle exposures, including nutrition, were determined by validated questionnaires. CVD was defined as coronary artery diseases, strokes, and peripheral artery diseases. Median serum calprotectin levels were 1.04 mg/L [IQR: 0.73–1.46 mg/L] and were higher in women (1.11 mg/L) than men (0.96 mg/L, p = 0.007). Current smoking was a major independent determinant of circulating calprotectin, with a 51% higher calprotectin compared to never smoking (p < 0.001). Albuminuria (p = 0.011), former smoking (p = 0.023), and intake of mono- and disaccharides (p = 0.005) also contributed independently to circulating calprotectin. Each incremental increase in calprotectin level was associated with 1.36-times higher odds for CVD (95% CI 1.04–1.77, p = 0.026). In the current study, calprotectin was the only inflammatory parameter significantly associated with CVD. The strong association of circulating calprotectin with smoking, a well-known direct cause of vascular inflammation, and also with CVD, stresses the urge for further research to define its role as a biomarker in T2DM.

【 授权许可】

Unknown