The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias

Cells

MariaD. Odero¹  Raffaella Pippa² 

[1] Centro de Investigación Médica Aplicada (CIMA), University of Navarra, 31008 Pamplona, Spain;Medical Oncology Department, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA;

关键词: pp2a;    myc;    myeloid leukemia;    aml;    cml;   

DOI  :  10.3390/cells9030544

来源: DOAJ

【 摘 要 】

The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptosis, and differentiation, and they, directly and indirectly, regulate each other’s activity. Studies in cancer suggest that targeting the MYC/PP2A network is an achievable strategy for the clinic. Here, we focus on and discuss the role of MYC and PP2A in myeloid leukemias.

【 授权许可】

Unknown