The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury

International Journal of Molecular Sciences

Fiorella Calabrese¹  Francesco Fortarezza¹  Stefania Rizzo¹  Monica De Gaspari¹  Cristina Basso¹  Matteo Fassan²  Giovanni Zarrilli²  Valentina Angerilli²  Gianluca Businello²  Angelo PaoloDei Tos²  Marta Sbaraglia²  Giulia Traverso³ 

[1] Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35121 Padua, Italy;Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, 35121 Padua, Italy;Istituto Oncologico Veneto, IOV-IRCCS, 35128 Padua, Italy;

关键词: SARS-CoV-2;    COVID19;    pathology;    cytokine storm;   

DOI  :  10.3390/ijms22020974

来源: DOAJ

【 摘 要 】

A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have focused on autopsy findings in COVID-19-related deaths to try and define any possible specific pattern. Histopathologic alterations are principally found within lungs and blood vessels, and these abnormalities also seem to have the highest clinical impact. Nevertheless, many of the morphological data collected so far are non-specific, fickle, and possibly associated with other co-existing factors. The aim of this minireview is to describe the main histopathological features related to COVID-19 and the mechanism known as “cytokine storm”.

【 授权许可】

Unknown