Health at Every Size®-Based Interventions May Improve Cardiometabolic Risk and Quality of Life Even in the Absence of Weight Loss: An Ancillary, Exploratory Analysis of the Health and Wellness in Obesity Study

Frontiers in Nutrition

Patricia Lopes de Campos-Ferraz¹  Isabel Perez¹  Priscila de Morais Sato¹  Ana Jéssica Pinto²  Fabiana B. Benatti²  Fernanda Sabatini²  André Vessoni³  Ramiro Fernandez Unsain³  Geni Sampaio³  Marcelo Macedo Rogero³  Mariana Dimitrov Ulian³  Bruno Gualano³  Luiz Aburad⁴  Fernanda B. Scagliusi⁵  Desire Coelho⁶  Odilon J. Roble⁶ 

[1] Nutrition Research Group, University of São Paulo, São Paulo, Brazil;;Applied Physiology &Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil;Faculty of Physical Education, State University of Campinas, Campinas, Brazil;Food Research Center (FoRC), CEPID-FAPESP, Research Innovation and Dissemination Centers São Paulo Research Foundation, São Paulo, Brazil;School of Applied Sciences, State University of Campinas, Limeira, Brazil;

关键词: obesity;    lifestyle intervention;    cardiovascular risk;    physical activity;    weight-neutral approach;   

DOI  :  10.3389/fnut.2022.598920

来源: DOAJ

【 摘 要 】

We examined whether weight loss following HAES®-based interventions associates with changes in cardiometabolic risk factors and quality of life of women with obesity. This was an exploratory, ancillary analysis of a 7-month, mixed-method, randomized controlled trial. Fifty-five women (age: 33.0 ± 7.2; BMI: 30–39.9 kg/m2) were included in this study. Body weight, cardiovascular risk factors, clustered cardiometabolic risk, and quality of life were assessed before (Pre) and after HAES®-based interventions (Post). Delta scores (Post-Pre) were calculated for each outcome and used in linear regression models. After adjusting by potential confounders, weight loss was associated with improvements in waist circumference (β = 0.83, p <0.001), fasting glycemia (β = 0.45, p = 0.036), total cholesterol (β = 1.48, p = 0.024), LDL (β = 1.33, p = 0.012), clustered cardiometabolic risk (β = 0.18, p = 0.006), and quality of life (β = −1.05, p = 0.007). All participants but one who reduced body weight (n = 11) improved clustered cardiometabolic risk and quality of life. Of relevance, 34% and 73% of the participants who maintained or gained weight improved clustered cardiometabolic risk and quality of life, respectively, although the magnitude of improvements was lower than that among those who lose weight. Improvements in cardiovascular risk factors and quality of life following HAES®-based interventions associated with weight loss as expected. However, most of the participants who maintained or even gained weight experienced benefits to some extent. This suggests that weight-neutral, lifestyle-modification interventions may improve wellness and health-related outcomes, even in the absence of weight loss.

【 授权许可】

Unknown