Nanoconjugate Synthesis of Elaeocarpus ganitrus and the Assessment of Its Antimicrobial and Antiproliferative Properties

Molecules

Raghu Ram Achar¹  Chandan Shivamallu¹  Sushma Pradeep²  Shashanka K Prasad²  Chandrashekar Srinivasa³  Lavanya Chandramouli⁴  Deepthi Bhaskar⁴  Sanjukta Mazumdar⁴  Arpitha Badarinath Mahajanakatti⁴  Rajeswari Narayanappa⁴  Sushravya Shetty⁴  Govindappa Melappa⁴  Victor Stupin⁵  Ekaterina Silina⁶  Telugu Seetharam Deepak⁷  Shiva Prasad Kollur⁸ 

[1]Department of Biochemistry, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India

[2]Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India

[3]Department of Biotechnology, Davangere University, Shivagangotri, Davangere 577002, Karnataka, India

[4]Department of Biotechnology, Dayananda Sagar College of Engineering, (Affiliated to VTU, Belagavi), Shavige Malleshwara Hills, Bengaluru 560078, Karnataka, India

[5]Department of Hospital Surgery, N.I. Pirogov Russian National Research Medical University (RNRMU), 117997 Moscow, Russia

[6]Department of Human Pathology, Institute of Biodesign and Modeling of Complex Systems, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia

[7]Ramaiah Medical College and Hospitals, New BEL Road, Bengaluru 560054, Karnataka, India

[8]School of Agriculture, Geography, Environment, Ocean and Natural Sciences, Laucala Campus, The University of the South Pacific, Suva, Fiji

关键词: rudraksha;    Elaeocarpus ganitrus;    anticancer;    antiproliferative;    molecular docking;   

DOI  :  10.3390/molecules27082442

来源: DOAJ

【 摘 要 】

Cancer is one of the leading causes of death worldwide, accountable for a total of 10 million deaths in the year 2020, according to GLOBOCAN 2020. The advancements in the field of cancer research indicate the need for direction towards the development of new drug candidates that are instrumental in a tumour-specific action. The pool of natural compounds proves to be a promising avenue for the discovery of groundbreaking cancer therapeutics. Elaeocarpus ganitrus (Rudraksha) is known to possess antioxidant properties and after a thorough review of literature, it was speculated to possess significant biomedical potential. Green synthesis of nanoparticles is an environmentally friendly approach intended to eliminate toxic waste and reduce energy consumption. This approach was reported for the synthesis of silver nanoparticles from two different solvent extracts: aqueous and methanolic. These were characterized by biophysical and spectroscopic techniques, namely, UV-Visible Spectroscopy, FTIR, XRD, EDX, DLS, SEM, and GC-MS. The results showed that the nanoconjugates were spherical in geometry. Further, the assessment of antibacterial, antifungal, and antiproliferative activities was conducted which yielded results that were qualitatively positive at the nanoscale. The nanoconjugates were also evaluated for their anticancer properties using a standard MTT Assay. The interactions between the phytochemicals (ligands) and selected cancer receptors were also visualized in silico using the PyRx tool for molecular docking.

【 授权许可】

Unknown