期刊论文详细信息
Molecules | |
Polyalkoxy Nitrones as Chiral Building Blocks in Asymmetric Synthesis | |
关键词: Nitrones; hydroxylamines; carbohydrates; aminoacids; aminoaldehydes; | |
DOI : 10.3390/40700169 | |
来源: DOAJ |
【 摘 要 】
Optically active nitrones derived from both aldoses and dialdoses add metallated heterocycles in a stereocontrolled way depending on the nature of the Lewis acid used as a precomplexing agent of the nitrone. Further elaborations of the resulting hydroxylamines lead to the development of new synthetic methodologies for the preparation of polyalkoxy α-amino aldehydes and α-amino acids. These compounds can be used as key advanced intermediates in the synthesis of a wide range of natural products and derivatives including amino sugars, aza sugars, and complex nucleosides.
【 授权许可】
Unknown