Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications

Molecules

Lorenzo Preti¹  Elena Marchesi¹  Daniela Perrone¹  MariaLuisa Navacchia² 

[1] Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy;Institute of Organic Synthesis and Photoreactivity National Research Council, 40129 Bologna, Italy;

关键词: click chemistry;    1,2,3-trizole;    azide-alkyne cycloaddition;    bioisosteres;    nucleosides;    nucleic acid;   

DOI  :  10.3390/molecules26113100

来源: DOAJ

【 摘 要 】

The click azide = alkyne 1,3-dipolar cycloaddition (click chemistry) has become the approach of choice for bioconjugations in medicinal chemistry, providing facile reaction conditions amenable to both small and biological molecules. Many nucleoside analogs are known for their marked impact in cancer therapy and for the treatment of virus diseases and new targeted oligonucleotides have been developed for different purposes. The click chemistry allowing the tolerated union between units with a wide diversity of functional groups represents a robust means of designing new hybrid compounds with an extraordinary diversity of applications. This review provides an overview of the most recent works related to the use of click chemistry methodology in the field of nucleosides, nucleotides and nucleic acids for pharmacological applications.

【 授权许可】

Unknown