A feasibility investigation of mindfulness-based cognitive therapy for people with Huntington’s disease

Pilot and Feasibility Studies

Dawn Rogers¹  David Craufurd¹  Siofra Peeren¹  Zara Skitt¹  Kristian Glenny²  Rachael Theed²  Fiona J. R. Eccles²  Leona Rose²  Alistair Smith²  Jane Simpson²  Max Homberger²  Rhys Davies³ 

[1] Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester;Division of Health Research, Faculty of Health and Medicine, Lancaster University;The Walton Centre NHS Foundation Trust;

关键词: Huntington’s disease;    Mindfulness;    Depression;    Anxiety;    Stress;   

DOI  :  10.1186/s40814-020-00631-z

来源: DOAJ

【 摘 要 】

Abstract Background Huntington’s disease (HD) is an inherited neurodegenerative condition which affects movement, coordination and cognitive functioning. Psychological difficulties are commonly experienced; however, psychological interventions have been little researched with this population. We investigated the feasibility of conducting a randomised controlled trial (RCT) of mindfulness-based cognitive therapy (MBCT) with people with the HD genetic mutation, either pre-manifest (before onset of movement symptoms) or at an early disease stage. Specifically, we evaluated the willingness of participants to be recruited into and complete the intervention; the acceptability of the study measures in relation to completion; the feasibility of offering the standard MBCT course to people with HD; the acceptability of the intervention and the estimated effect sizes. Methods Participants were recruited from two UK HD centres and took part in an 8-week course of MBCT, with three reunions throughout the following year. Stress, depression, anxiety, and mindfulness were measured pre-, mid-, and post-course, at 3 months and at 1 year. Sleep, quality of life, positive affect and coping were measured pre- and post-course, at 3 months and at 1 year. Descriptive data and approximate effect sizes were calculated. Interviews were conducted post-course and at 1 year and data pertaining to the acceptability of the course were extracted. Results Twelve participants took part in two groups; all were pre-manifest. Levels of depression and anxiety were low pre-course leaving little room for improvement. Changes in stress and in some aspects of mindfulness were medium to large. The qualitative data suggested participants rated the course highly and found it helpful and no changes to the standard course were needed. Recruitment levels were below those anticipated. Most measures were found to be acceptable. Conclusions Although the course was acceptable to those who took part, given the difficulties in recruiting and the rarity of HD, conducting an RCT of MBCT teaching groups in person does not seem feasible. However, alternative modes of course delivery (e.g. online) would allow the recruitment of people from a greater geographical area and may make an RCT feasible; this revised focus would be suitable for future feasibility studies. Trial registration ClinicalTrials.gov identifier NCT02464293 , registered 8 June 2015.

【 授权许可】

Unknown