An Increased Understanding of Enolate Additions under Mechanochemical Conditions

Molecules

James Mack¹  Heather Hopgood¹ 

[1] Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA;

关键词: mechanochemistry;    green chemistry;    enolate;    solvent-free;   

DOI  :  10.3390/molecules22050696

来源: DOAJ

【 摘 要 】

Very little is known about enolate addition chemistry under solver-free mechanochemical conditions. In this report, we investigated the ability to selectively form products arising from the primary, secondary, and tertiary enolates under solvent-free conditions. Using potassium tert-butoxide as the base and primary, secondary, and tertiary electrophiles, we were able to generate various enolate addition products including, 1,3,3,3-tetraphenyl-2,2-dimethyl-1-propanone; a molecule we did not observe under traditional solution-based conditions.

【 授权许可】

Unknown