Tranexamic Acid for Shoulder Arthroplasty: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine

Adam Smereka¹  Ewa Manka²  Jaroslaw Pecold³  Mahdi Al-Jeabory³  Maciej Krupowies⁴  Lukasz Szarpak⁴  Jerzy Robert Ladny⁴ 

[1] Department of Gastroenterology and Hepatology, Faculty of Medicine, Wroclaw Medical University, 53-126 Wroclaw, Poland;Department of Internal Medicine, Angiology and Physical Medicine in Bytom, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland;Department of Trauma and Orthopedic Surgery, Ruda Slaska City Hospital, 41-703 Ruda Slaska, Poland;Research Unit, Polish Society of Disaster Medicine, 05-806 Warsaw, Poland;

关键词: tranexamic acid;    TXA;    shoulder;    arthroscopy;    bleeding;    systematic review;   

DOI  :  10.3390/jcm11010048

来源: DOAJ

【 摘 要 】

Tranexamic acid (TXA) is an antifibrinolytic agent that has been shown to decrease blood loss and transfusion rates after knee and hip arthroplasty, however with only limited evidence to support its use in shoulder arthroplasty. Therefore, we performed a systematic review and meta-analysis to evaluate the clinical usefulness of tranexamic acid for shoulder arthroplasty. A thorough literature search was conducted across four electronic databases (PubMed, Cochrane Library, Web of Science, Scopus) from inception through to 1 December 2021. The mean difference (MD), odds ratio (OR) or relative risk (RR) and 95% confidence interval (CI) were used to estimate pooled results from studies. Total of 10 studies comprising of 993 patients met the inclusion criteria and were included in the analysis. Blood volume loss in the TXA and non-TXA group was 0.66 ± 0.52 vs. 0.834 ± 0.592 L (MD= −0.15; 95%CI: −0.23 to −0.07; p < 0.001). Change of hemoglobin levels were 2.2 ± 1.0 for TXA group compared to 2.7 ± 1.1 for non-TXA group (MD= −0.51; 95%CI: −0.57 to −0.44; p < 0.001) and hematocrit change was 6.1 ± 2.7% vs. 7.9 ± 3.1%, respectively; (MD= −1.43; 95%CI: −2.27 to −0.59; p < 0.001). Tranexamic acid use for shoulder arthroplasty reduces blood volume loss during and after surgery and reduces drain output and hematocrit change.

【 授权许可】

Unknown