Alzheimer’s disease pattern derived from relative cerebral flow as an alternative for the metabolic pattern using SSM/PCA

EJNMMI Research

Remco J. Renken¹  Peter P. De Deyn²  Fransje E. Reesink²  Bauke M. de Jong²  Débora E. Peretti³  David Vállez García³  Janine Doorduin³  Rudi A. J. O. Dierckx³  Ronald Boellaard³ 

[1] Department of Biomedical Sciences of Cells and Systems, Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen;Department of Neurology, Alzheimer Centre, University Medical Center Groningen, University of Groningen;Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen;

关键词: Alzheimer’s disease;    Disease pattern;    Relative cerebral blood flow;    SSM/PCA;   

DOI  :  10.1186/s13550-022-00909-8

来源: DOAJ

【 摘 要 】

Abstract Background 2-Deoxy-2-[18F]fluoroglucose (FDG) PET is an important tool for the identification of Alzheimer’s disease (AD) patients through the characteristic neurodegeneration pattern that these patients present. Regional cerebral blood flow (rCBF) images derived from dynamic 11C-labelled Pittsburgh Compound B (PIB) have been shown to present a similar pattern as FDG. Moreover, multivariate analysis techniques, such as scaled subprofile modelling using principal component analysis (SSM/PCA), can be used to generate disease-specific patterns (DP) that may aid in the classification of subjects. Therefore, the aim of this study was to compare rCBF AD-DPs with FDG AD-DP and their respective performances. Therefore, 52 subjects were included in this study. Fifteen AD and 16 healthy control subjects were used to generate four AD-DP: one based on relative cerebral trace blood (R 1), two based on time-weighted average of initial frame intervals (ePIB), and one based on FDG images. Furthermore, 21 subjects diagnosed with mild cognitive impairment were tested against these AD-DPs. Results In general, the rCBF and FDG AD-DPs were characterized by a reduction in cortical frontal, temporal, and parietal lobes. FDG and rCBF methods presented similar score distribution. Conclusion rCBF images may provide an alternative for FDG PET scans for the identification of AD patients through SSM/PCA.

【 授权许可】

Unknown