Diagnostic Accuracy of the Five-Word Test for Mild Cognitive Impairment Due to Alzheimer’s Disease

Neurology International

Chiara Fornari¹  Nicola Zoppi²  Chiara Silvestri²  Ilenia Libri²  Matteo Maffi³  Maura Cosseddu³  Salvatore Caratozzolo³  Alessandro Padovani³  Barbara Borroni³  Rosanna Turrone³  Alberto Benussi³  Francesco Mori³ 

[1] Centre for Mind/Brain Sciences CIMeC, University of Trento, 38123 Rovereto, Italy;Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy;Neurology Unit, Department of Neurological and Vision Sciences, ASST Spedali Civili di Brescia, 25123 Brescia, Italy;

关键词: AD-MCI;    CSF biomarkers;    t-Tau;    p-Tau₁₈₁;    Aβ_1–42;    amyloid-PET imaging;   

DOI  :  10.3390/neurolint14020029

来源: DOAJ

【 摘 要 】

New diagnostic methods have been developed for the early diagnosis of Alzheimer’s disease (AD) with the primary purpose of intercepting the transition-phase (mild cognitive impairment, MCI) between normal aging and dementia. We aimed to explore whether the five-word test (FWT) and the mini-mental state examination (MMSE) are predictive for the early diagnosis of MCI due to AD (AD-MCI). We computed ROC analyses to evaluate the sensitivity and specificity of MMSE and FWT in predicting abnormal CSF (t-Tau, p-Tau₁₈₁, Aβ_1–42) and amyloid-PET biomarkers. AD-MCI patients showed lower MMSE and FWT scores (all p < 0.001) than non-AD-MCI. The best predictor of amyloid plaques’ presence at amyloid-PET imaging was the encoding sub-score of the FWT (AUC = 0.84). Both FWT and MMSE had low/moderate accuracy for the detection of pathological CSF Aβ₄₂, t-Tau and p-Tau₁₈₁ values, with higher accuracy for the t-Tau/Aβ_1–42 ratio. In conclusion, the FWT, as a single-domain cognitive screening test, seems to be prompt and moderately accurate tool for the identification of an underlying AD neuropathological process in patients with MCI, supporting the importance of associating biomarkers evaluation in the work-up of patients with dementing neurodegenerative disorders.

【 授权许可】

Unknown