COVID-19 Sepsis and Microcirculation Dysfunction

Frontiers in Physiology

Gregorio Caimi¹  Antonio Colantuoni²  Agostino Gnasso³  Pier Leopoldo Capecchi⁴  Rosalia Lo Presti⁵  Marco Rossi⁶  Patrizia Caprari⁷  Marco Ballestri⁸  Antonella Marcoccia⁹  Romeo Martini^1,10 

[1] 0Department of Science for Health Promotion and Mother to Child Care, University of Palermo, Palermo, Italy;Department of Clinical Medicine and Surgery, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy;Department of Clinical and Experimental Medicina, Magna Graecia University of Catanzaro, Catanzaro, Italy;Department of Medical, Surgical and Neuroscience Sciences, University of Siena, Siena, Italy;Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy;Dipartimento di Medicina Interna, Università di Pisa, Pisa, Italy;Istituto Superiore di Sanità (ISS), Rome, Italy;Nephrology Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy;UOD Vascular Medicine and Auto-immunity, Sandro Pertini Hospital, Rome, Italy;Unit of Angiology, Department of Cardio Thorax and Vascular Sciences, Azienda Ospedaliera Universitaria Padova, Padua, Italy;

关键词: COVID-19;    microcirculation;    endothelial cells;    angiotensin II;    thromboxane (TxB2);   

DOI  :  10.3389/fphys.2020.00747

来源: DOAJ

【 摘 要 】

The spreading of Coronavirus (SARS-CoV-2) pandemic, known as COVID-19, has caused a great number of fatalities all around the World. Up to date (2020 May 6) in Italy we had more than 28,000 deaths, while there were more than 205.000 infected. The majority of patients affected by COVID-19 complained only slight symptoms: fatigue, myalgia or cough, but more than 15% of Chinese patients progressed into severe complications, with acute respiratory distress syndrome (ARDS), needing intensive treatment. We tried to summarize data reported in the last months from several Countries, highlighting that COVID-19 was characterized by cytokine storm (CS) and endothelial dysfunction in severely ill patients, where the progression of the disease was fast and fatal. Endothelial dysfunction was the fundamental mechanism triggering a pro-coagulant state, finally evolving into intravascular disseminated coagulation, causing embolization of several organs and consequent multiorgan failure (MOF). The Italian Society of Clinical Hemorheology and Microcirculation was aimed to highlight the role of microcirculatory dysfunction in the pathogenetic mechanisms of COVID-19 during the spreading of the biggest challenges to the World Health.

【 授权许可】

Unknown