Upper Gastrointestinal Lesions during Endoscopy Surveillance in Patients with Lynch Syndrome: A Multicentre Cohort Study

Cancers

Gabriel Rahmi¹  Christophe Cellier¹  Elia Samaha¹  David Tougeron²  Thierry Barrioz²  Thierry Lecomte³  Didier Barbereau³  Romain Chautard³  Sandrine Feau³  Olivier Caron⁴  David Malka⁴ 

[1] Department of Gastroenterology, European Georges Pompidou Hospital, Assistance Publique Hôpitaux de Paris, 75015 Paris, France;Department of Gastroenterology, Poitiers University Hospital, 86021 Poitiers, France;Department of Hepatogastroenterology and Digestive Oncology, Trousseau University Hospital, CHU de Tours, CEDEX 09, 37044 Tours, France;Gastrointestinal Oncology Unit, Department of Oncologic Medicine, Institut Gustave Roussy, Université Paris Sud, 94805 Villejuif, France;

关键词: Lynch syndrome;    upper gastrointestinal endoscopy;    gastric cancer;    duodenal cancer;    screening;    Helicobacter pylori;   

DOI  :  10.3390/cancers13071657

来源: DOAJ

【 摘 要 】

Background: Patients with Lynch syndrome are at increased risk of gastric and duodenal cancer. Upper gastrointestinal endoscopy surveillance is generally proposed, even though little data are available on upper gastrointestinal endoscopy in these patients. The aim of this retrospective study was to evaluate the prevalence and incidence of gastrointestinal lesions following upper gastrointestinal endoscopy examination in Lynch patients. Methods: A large, multicentre cohort of 172 patients with a proven germline mutation in one of the mismatch repair genes and at least one documented upper gastrointestinal endoscopy screening was assessed. Detailed information was collected on upper gastrointestinal endoscopy findings and the outcome of endoscopic follow-up. Results: Seventy neoplastic gastrointestinal lesions were diagnosed in 45 patients (26%) out of the 172 patients included. The median age at diagnosis of upper gastrointestinal lesions was 54 years. The prevalence of cancer at initial upper gastrointestinal endoscopy was 5% and the prevalence of precancerous lesions was 12%. Upper gastrointestinal lesions were more frequent after 40 years of age (p < 0.001). Helicobacter pylori infection was associated with an increased prevalence of gastric, but not duodenal, lesions (p < 0.001). Conclusions: Neoplastic upper gastrointestinal lesions are frequent in patients with Lynch syndrome, especially in those over 40 years of age. The results of our study suggest that Lynch patients should be considered for upper gastrointestinal endoscopic and Helicobacter pylori screening.

【 授权许可】

Unknown