The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review

Frontiers in Endocrinology

Tim G. De Meij¹  Nina Frerichs¹  Irwin K. M. Reiss²  Thomas Hankemeier³  Emma Ronde⁴  Sam Schoenmakers⁴ 

[1] Department of Pediatric Gastroenterology, Amsterdam University Medical Centre, Amsterdam, Netherlands;Department of Pediatrics, Division of Neonatology, Erasmus University Medical Centre, Rotterdam, Netherlands;Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands;Division of Obstetrics and Prenatal Diagnosis, Erasmus University Medical Centre, Rotterdam, Netherlands;

关键词: preterm delivery;    metabolomics;    microbiota;    VOC;    metabolites;    biomarkers;   

DOI  :  10.3389/fendo.2021.668417

来源: DOAJ

【 摘 要 】

Scopeas the leading cause of perinatal mortality and morbidity worldwide, the impact of premature delivery is undisputable. Thus far, non-invasive, cost-efficient and accurate biochemical markers to predict preterm delivery are scarce. The aim of this systematic review is to investigate the potential of non-invasive metabolomic biomarkers for the prediction of preterm delivery.Methods and ResultsDatabases were systematically searched from March 2019 up to May 2020 resulting in 4062 articles, of which 45 were retrieved for full-text assessment. The resulting metabolites used for further analyses, such as ferritin, prostaglandin and different vitamins were obtained from different human anatomical compartments or sources (vaginal fluid, serum, urine and umbilical cord) and compared between groups of women with preterm and term delivery. None of the reported metabolites showed uniform results, however, a combination of metabolomics biomarkers may have potential to predict preterm delivery and need to be evaluated in future studies.

【 授权许可】

Unknown