2-Alkylation of 3-Alkyindoles With Unactivated Alkenes

Frontiers in Chemistry

关键词: metal-free;    acid catalysis;    atom economy;    indole-2-alkylation;    alkene;   

DOI  :  10.3389/fchem.2022.860764

来源: DOAJ

【 摘 要 】

An acid-catalyzed 2-alkylation of indole molecules is developed. Only catalytic amount of the commercially available, inexpensive and traceless HI is used as the sole reaction promoter. 2,3-Disubstituted indole molecules bearing congested tertiary carbon centers are afforded as the final products in moderate to excellent yields.

【 授权许可】

Unknown